The final countdown has begun and Chelsea Handler is leaving E! In just a matter of days , the HIGHlarious Chelsea Lately show we’ve all come to know and love is ending. Although Chelsea will be continuing her comedic and talk show abilities on another network , don’t expect her to leave quietly! She’s got big surprises for her final hoorah and one of them is Miley Cyrus ! The Bangerz singer is confirmed to send Chelsea off with a performance of Roy Orbison ‘s song, It’s Over — which will probably be a pretty emotional performance, judging by the title of the song.