The Vampire Diaries’ Caroline, played by Candice Accola, was dealt a major blow in the midseason finale when she learned that her mother has inoperable, chemo-resistant tumor. At the time, the program’s showrunner Caroline Dries teased, “She’s going to try and take matters in her own hands, only to realize, some things there is no cure for.” At first, Caroline is content to give her mother kale smoothies and extra blankets, though, she’s frustrated about the slowness of “modern medicine” — but when she presses a visiting Damon about lack of support for her idea to give Sheriff Forbes some vampire blood, she’s stunned when he informs her she doesn’t actually have his support.